Correction: Phosphatase, pseudo-phosphatase, or both? Understanding PRL oncogenicity
نویسندگان
چکیده
منابع مشابه
PRL-3 phosphatase is implicated in ovarian cancer growth.
PURPOSE The PRL-3 phosphatase has been found expressed at higher levels in metastasis than in primary tumors of patients with colorectal cancer. In the present study, we evaluated the expression of PRL-3 in ovarian cancer tissue and its role in ovarian cancer cell growth. EXPERIMENTAL DESIGN PRL-3 phosphatase expression was evaluated in 84 ovarian tumor samples. PRL-3 expression has been knoc...
متن کاملRegulatory mechanisms of phosphatase of regenerating liver (PRL)-3
The phosphatase of regenerating liver (PRL)-3 is overexpressed in many human cancer types and tumor metastases when compared with healthy tissues. Different pathways and mechanisms have been suggested to modulate PRL-3 expression levels and activity, giving some valuable insights but still leaving an incomplete picture. Investigating these mechanisms could provide new targets for therapeutic dr...
متن کاملStructural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.
Phosphatases of regenerating liver (PRLs), the most oncogenic of all protein-tyrosine phosphatases (PTPs), play a critical role in metastatic progression of cancers. Recent findings established a new paradigm by uncovering that their association with magnesium transporters of the cyclin M (CNNM) family causes a rise in intracellular magnesium levels that promote oncogenic transformation. Recent...
متن کاملIs CdtB a nuclease or a phosphatase?
Lara-Tejero and Galán (1) reported deoxyribonuclease (DNase) I–like activity of cytolethal distending toxin B (CdtB), which causes arrest in the G2/M transition phase of the cell cycle (2). Even though the authors noted that CdtB is a poor nuclease in vitro, they proposed that CdtB-inflicted DNA damage could trigger the checkpoint system that prevents cell entry into mitosis. A relationship bet...
متن کاملIndependent oncogenic and therapeutic significance of phosphatase PRL-3 in FLT3-ITD–negative acute myeloid leukemia
BACKGROUND Internal tandem duplication of FMS-like tyrosine kinase (FLT3-ITD) is well known to be involved in acute myeloid leukemia (AML) progression, but FLT3-ITD-negative AML cases account for 70% to 80% of AML, and the mechanisms underlying their pathology remain unclear. This study identifies protein tyrosine phophatase PRL-3 as a key mediator of FLT3-ITD-negative AML. METHODS A total of...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2021
ISSN: 0007-0920,1532-1827
DOI: 10.1038/s41416-021-01311-2